PhD Project “Centriole regulation in health and disease” (Schiebel/ Pereira) – Heidelberg University

Organisation/Company

HBIGS Heidelberg Biosciences International Graduate School

Department

Faculty of Biosciences

Research Field

Biological sciences » Biology

Researcher Profile

First Stage Researcher (R1)

Country

Germany

Application Deadline

30 Mar 2024 – 23:30 (Europe/Brussels)

Type of Contract

Temporary

Job Status

Full-time

Hours Per Week

40

Offer Starting Date

2 Jan 2024

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

We are seeking for two motivated PhD students interested in basic and applied centriole research related to human disease. The centriole is a microtubule-based structure that is important for mitotic spindle formation and assembly of the primary cilium, an essential signalling organelle. Duplication, length and structure of centrioles are highly regulated by a protein network, represented by the protein CEP350, which prevents centriole overduplication, over-elongation or fragmentation. Defects in this network are the cause of inherited disease and are linked to cancer. This project combines the expertise of the Pereira and Schiebel laboratories in cilia formation and centriole biology. 

It aims to understand the function and regulation of the CEP350 network and how its malfunction leads to disease. The project involves genome editing, the use of protein degrons for the rapid depletion of proteins, phospho-proteome analysis, and advanced microscopy (live cell image, ultra-expansion and electron microscopy).

Requirements

Research Field

Biological sciences » Biology

Education Level

Master Degree or equivalent

Skills/Qualifications

Applicants should have a strong background in cell or molecular biology and a special interest in centrosome and cilia formation. 

Languages

ENGLISH

Level

Good

Additional Information
Selection process

Applications should be sent per email to both, Gislene Pereira ([email protected] ) and Elmar Schiebel ([email protected] ), and include a letter of motivation, a CV, name of 2-3 referees and a copy of Bachelor and Master transcripts.

Additional comments

One student will work in the Pereira lab at COS and the other in the Schiebel lab at the ZMBH. Both PhD students will be members of the Heidelberg Biosciences International Graduate School (HBIGS) (http://www.hbigs.uni-heidelberg.de/ ). 

The PhD positions are funded in the first instance for 3 years.

Website for additional job details

https://www.hbigs.uni-heidelberg.de

Work Location(s)

Number of offers available

1

Company/Institute

Center for Molecular Biology (ZMBH) and Center for Organismal Studies (COS)

Country

Germany

City

Heidelberg

Postal Code

69120

Street

INF 282 and INF 230

Where to apply

E-mail

[email protected]

Contact

City

Heidelberg

Website

http://www.hbigs.uni-heidelberg.de/

Street

Im Neuenheimer Feld 501

Postal Code

69120

E-Mail

[email protected]

STATUS: EXPIRED