Royal College of Surgeons in Ireland
Job title:
Postdoctoral Fellow (Cancer Microbiome and Single Cell Research)
Company
Royal College of Surgeons in Ireland
Job description
Job Information Organisation/Company
RCSI – Royal College of Surgeons in Ireland Department
Human Resources Research Field
Medical sciences » Health sciences Researcher Profile
First Stage Researcher (R1) Country
Ireland Application Deadline
2 Apr 2024 – 23:45 (Europe/Dublin) Type of Contract
Temporary Job Status
Full-time Hours Per Week
39 Offer Starting Date
1 May 2024 Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
Job Title: Postdoctoral Fellow (Cancer Microbiome and Single Cell Research)
Department: Physiology & Medical Physics
Reporting to: Jochen Prehn
Location: 123 St Stephens Green
Contract/Duration: 24 Months (1FTE)
Remuneration: IUA Postdoctoral researcher Level 1 point 2
Closing Date: Tuesday April 2nd 2024
About Our Research
RCSI recognises that excellence in research is critical to the quality of its educational activities, its credibility, and, overall, to its mission to enhance human health. RCSI’s research strategy aims to build upon its strength in translational biomedical and clinical research to deliver transformational, high impact changes in health care. Targeting both Irish national and EU funding, along with increased collaboration with industry, is a major part of the RCSI research strategy. Forging increased collaboration between RCSI PIs and industry is of critical importance to achieving success in this area. RCSI is also committed to provide its researchers with the supports and developmental opportunities to enable them to continuously grow and support their overall career development.
Summary of Post
We will build a Single-Cell Atlas of Fusobacterium Infection and the Cellular Signalling Response in the different cell types of the tumour microenvironment infected with Fusobacterium (cancer cells, fibroblasts, immune cells, endothelial cells). Hyperplexed immunofluorescence imaging will be performed in colorectal cancer tissues using the Cell DIVE platform in Prof Prehn’s laboratory. Tissue section will be stained for Fusobacterium and 20-30 rationally-selected markers identifying the different cell types and their responses to infection (including protein markers of inflammation, apoptosis and cell death, Wnt signalling, DNA damage, and cell proliferation).
The spatial effects of infection on tumours will be evaluated in all tumour cores and in a subset of whole slide sections including cell/biomarker responses locally/distant from infection, cell interactions, immune infiltration and association with tumour vasculature. The contribution of infection associated spatial metrics to outcomes will be assessed.
Specifically, the duties of the post are:
- Conduct individual and/or collaborative research producing excellent research outputs to the highest ethical standards in a variety of settings as outlined above.
- Engage in the dissemination of the results of the research in which you are engaged in for relevant research stakeholders in the appropriate form.
- Carry out any administration/management associated with your programme of research.
- Promoting translational research through interaction with the other team members, RCSI staff and Research Institute and other relevant bodies.
- The candidate might be requested to assist with the supervision of graduate students and technical staff.
- Complying with statutory legislation, RCSI and department rules and requirements in furtherance of your own and general staff welfare and safety
- Undergoing programmes of training and development as may be required from time to time
- Representing the best interests of the Department and RCSI at all times
- Performing such other duties as may be required from time to time
Requirements
Research Field Medical sciences » Cancer research Education Level PhD or equivalent
Skills/Qualifications
Qualifications – (Essential):
- The candidate should have a Ph.D. (or submitted Ph.D. thesis) in Biochemistry, Cell Biology, Molecular Pathology or similar discipline, ideally in the field of Cancer Biology.
- Experience in microbiome research or multiplexing is of advantage
- Very good writing skills
- Effective communications style
- Proficiency in Computer/Presentation skills
- Ability to make decisions and meet deadlines
- Ability to work on one’s own initiative as well as in a team environment
Knowledge & Experience – (Essential):
- Excellent cell culturing, molecular biology and gene editing skills essential.
- Strong research and scientific writing skills.
- Ability to work successfully and engage positively with colleagues, collaborators and project stakeholders.
- Excellent organisational and communication skills
Knowledge & Experience – (Desirable):
- Experience with microscopy, spatial omics or multiplexing would be helpful but not necessary as training in these will be provided in RCSI.
- Experience with translational cancer research
- Bioinformatic skills would be desirable.
Desirable attributes include:
- Very strong research skills and a proven track record in publication of good research in this area.
- An understanding of the field of Colorectal Cancer and/or microbiome research.
- Excellent interpersonal, communication and presentation skills
- Experience with quantitative research methodologies
- Attention to detail and thoroughness in work practices and an ability to work to deadlines
- A capacity to work collaboratively as part of a team as well as independently, in a non-structured environment
- An ability to win the confidence of stakeholders, researchers and research partner representatives
- An ability to foster and sustain academic relationships internally and externally
We are all too aware that imposter syndrome and the confidence gap can sometimes stop fantastic candidates putting themselves forward, so please do submit an application – we’d love to hear from you. #rcsiar
Languages ENGLISH Level Excellent
Research Field Medical sciences » Cancer research Years of Research Experience 1 – 4
Additional Information
Benefits
Employee Benefits
RCSI make sure you have the resources you need to thrive by offering a wide range of benefits in areas including time away, finance, community, health, and well-being and insuring your financial future. Below are some additional benefits available to you as an RCSI employee:
- Minimum of 20 days annual leave, plus an additional 6.5 Privilege days
- Flexible/hybrid working options for colleagues across many roles
- Additional leave options incl. paid maternity leave, paternity/parental leave, study leave
- 7% Employer pension contribution
- Onsite gym €10 per/mth incl. classes and PT sessions
- Childcare support 20% discount at Giraffe
- Free eye test and annual flu vaccination
- TaxSaver commuter tickets and Bike to Work schemes
- A site sustainability team focusing on the environmental initiatives; Green Campus Initiative ‘
- Competitively priced café and restaurant
- Equality, Diversity & Inclusion forums, and network groups
- Employee assistance programme with Spectrum Life
- Learning and Development training programmes incl. LinkedIn Learning for career progression
- Discounted services incl. GP visits, 10% off dental, staff parking, mobile tariffs, Group Scheme discount on numerous brands
- Sports and social club incl. yoga, Pilates, fitness classes, Zumba, running club, social evenings, Summer BBQ
- Ticket Draws for events including; Rugby, Taste of Dublin, Dublin Horse Show, theatre, music & comedy events
Additional comments
Application Process
Please apply online through the RCSI careers portal on the closing date with your CV and cover letter.
Informal Enquiries can be directed to Prof Jochen Prehn ( ). Please note we do not accept CVs directly.
Work Location(s)
Number of offers available 1 Company/Institute Royal College of Surgeons in Ireland Country Ireland Geofield
Where to apply Website
Contact City
Dublin Website
Street
121/122 St. Stephen’s Green
STATUS: EXPIRED
Expected salary
Location
Dublin
Job date
Fri, 01 Mar 2024 04:27:22 GMT
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