Postdoctoral Research Associate: Axon Regeneration and Neuroprotection In The Visual System

Job title:

Postdoctoral Research Associate: Axon Regeneration and Neuroprotection In The Visual System

Company

King’s College London

Job description

Postdoctoral Research Associate: Axon Regeneration and Neuroprotection In The Visual SystemEmployer Location London (Central), London (Greater) Salary £44,105 – £50,163 per annum, including London weighting allowance Closing date 12 Jan 2025View more categoriesView less categoriesAcademic Discipline , , Job Type , Contract Type HoursSave jobClick to add the job to your shortlistYou need to or to save a job.Job DetailsAbout UsWolfson SPaRC (Sensory, Pain and Regeneration Centre) is one of four departments in the School of Neuroscience at the Institute of Psychiatry, Psychology & Neuroscience, King’s College London, and is located on the Guy’s Campus at London Bridge. Research in the department spans three main themes: Chronic Pain & Migraine, Spinal Cord & Brain Repair, and Hearing Loss & Sensory Systems. Our fundamental mission is to understand the biological mechanisms behind these neurological and sensory disorders and harness this knowledge to develop new therapeutic strategies.We have world-leading experts who interrogate these conditions at the genetic, molecular, cellular, and whole systems level. Cross-cutting strengths lie in our world-leading expertise in neuroplasticity, interdisciplinary neuro-immune research, high-throughput sequencing technologies, drug discovery and advanced therapeutics. We have excellent facilities to support our parallel use of pre-clinical cell and in vivo models, alongside human cellular models, which provides an essential platform for us to forward- and back-translate our fundamental research to and from the clinic.About the RoleApplications are invited for a postdoctoral research associate to join a project investigating new approaches for retinal neuroprotection and restoration of vision. The research is a part of a large project to identify and develop new treatments for glaucoma and spinal cord injury. Neurodegenerative diseases such as glaucoma cause irreversible damage to neurons in the retina and optic nerve, leading to a loss of vision. Spinal cord injury causes irreversible damage to axons which control movement and sensation.The role will use preclinical models to test and develope gene therapy approaches for retinal neuroprotection and optic nerve regeneration, whist using cell and molecular techniques to study the mechanisms controlling axon regeneration, and bespoke bioinformatic approaches for target identification.The work will involve collaborating with researchers and partners aiming to move treatments towards clinical treatments, with collaborations in London, Cambridge and Stockholm (Karolinska Institutet).Axon regeneration through the optic nerve and on towards the visual centres of the brain will be necessary as a regenerative treatment for glaucoma. The project will address this challenge by focusing on Protrudin, a scaffolding molecule that localizes to axon growth tips and brings together many of the components needed for axon growth including recycling endosomes, motor proteins and the endoplasmic reticulum.The work is part of a large project to repair the CNS by stimulating the transport of regenerative machinery into axons in the optic nerve or spinal cord. The Eva Lab is studying the role of various sub-cellular organelles during axon growth and regeneration, using several models of axonal injury.The position, funded by the MRC , will focus on Protrudin and related molecules as targets for stimulating guided regeneration through the diseased or injured nerve.This is a full time post and you will be offered an a fixed term contract until 5 Janaury 2028.About YouTo be successful in this role, we are looking for candidates with expertise in animal models of disease or injury, preferably with a background in eye or neuro -biology. Education to PhD level is required, with candidates demonstrating an intellectually and technically impressive track record.Essential criteria * PhD qualified in relevant subject area (or pending results following your final submission).

• Experience working with in vivo models of disease or injury, preferably in the visual system.
• Evidence of engagement in high quality research activity.
• Excellent organizational and administrative skills.

Desirable criteriaAbility to exercise a degree of innovation and creative problem solving.Experience with:Microscopy.Neuronal Cell Culture.Standard Biochemical Techniques.Molecular biology / DNA cloning.Bioinformatics.Downloading a copy of our Job DescriptionFull details of the role and the skills, knowledge and experience required can be found in the Job Description document, provided at the bottom of the next page after you click “Apply Now”. This document will provide information of what criteria will be assessed at each stage of the recruitment process.

• Please note that this is a PhD level role but candidates who have submitted their thesis and are awaiting award of their PhDs will be considered. In these circumstances the appointment will be made at Grade 5, spine point 30 with the title of Research Assistant. Upon confirmation of the award of the PhD, the job title will become Research Associate and the salary will increase to Grade 6.

Further InformationWe pride ourselves on being inclusive and welcoming. We embrace diversity and want everyone to feel that they belong and are connected to others in our community.We are committed to working with our staff and unions on these and other issues, to continue to support our people and to develop a diverse and inclusive culture at King’s.We ask all candidates to submit a copy of their CV, and a supporting statement, detailing how they meet the essential criteria listed in the advert. If we receive a strong field of candidates, we may use the desirable criteria to choose our final shortlist, so please include your evidence against these where possible.To find out how our managers will review your application, please take a look at our pages.Interviews are due to be held late January.CompanyKing’s College London is one of the top 20 universities in the world and among the oldest in England. King’s has more than 27,600 students (of whom nearly 10,500 are graduate students) from some 150 countries worldwide, and some 6,800 staff.King’s has an outstanding reputation for world-class teaching and cutting-edge research. In the 2014 Research Excellence Framework (REF) King’s was ranked 6th nationally in the ‘power’ ranking, which takes into account both the quality and quantity of research activity, and 7th for quality according to Times Higher Education rankings. Eighty-four per cent of research at King’s was deemed ‘world-leading’ or ‘internationally excellent’ (3* and 4*). The university is in the top seven UK universities for research earnings and has an overall annual income of more than £684 million.King’s has a particularly distinguished reputation in the humanities, law, the sciences (including a wide range of health areas such as psychiatry, medicine, nursing and dentistry) and social sciences including international affairs. It has played a major role in many of the advances that have shaped modern life, such as the discovery of the structure of DNA and research that led to the development of radio, television, mobile phones and radar.King’s College London and Guy’s and St Thomas’, King’s College Hospital and South London and Maudsley NHS Foundation Trusts are part of King’s Health Partners. King’s Health Partners Academic Health Sciences Centre (AHSC) is a pioneering global collaboration between one of the world’s leading research-led universities and three of London’s most successful NHS Foundation Trusts, including leading teaching hospitals and comprehensive mental health services. For more information, visit: .King’s £600 million campaign, World questions|KING’s answers, has delivered huge global impact in areas where King’s has particular expertise. Philanthropic support has funded new research to save young lives at Evelina London Children’s Hospital; established the King’s Dickson Poon School of Law as a worldwide leader in transnational law; built a new Cancer Centre at Guy’s Hospital; allowed unique collaboration between leading neuroscientists to fast-track new treatments for Alzheimer’s, Parkinson’s, motor neurone disease, depression and schizophrenia at the new Maurice Wohl Clinical Neuroscience Institute; created the Cicely Saunders Institute: the first academic institution in the world dedicated to palliative care, and supported the King’s Sierra Leone Partnership in the Ebola crisis. Donations provide over 300 of the most promising students with scholarships and bursaries each year. More information about the campaign is available at .Company info Mini-site Telephone +(44)02078365454 Location STRAND
LONDON
WC2R 2LS
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Expected salary

£44105 – 50163 per year

Location

Central London

Job date

Wed, 18 Dec 2024 08:34:43 GMT

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